Cholestasis Symptoms in Child

Joel E Lavine MD


If your child has cholestasis Symptoms, your doctor will likely perform additional tests to determine if the liver is functioning normally or inflamed. These tests are a non-invasive way of checking for liver disease and determining its severity. Your doctor will also do other tests to determine the underlying cause of cholestasis.


Cholestasis is a disease in which the flow of bile in the biliary system is impaired. This results in abnormal levels of bilirubin in the serum. This can affect the child’s overall health, including psychosocial functioning and quality of life. Bile helps the digestive system absorb dietary fat and eliminate bilirubin, a waste product of the breakdown of red blood cells. Bile comprises water, electrolytes, cholesterol, and other substances.

Children with cholestasis should undergo an assessment immediately, as it can lead to severe complications. This disorder may be caused by neonatal iron storage disease or viral infections. During pregnancy, the mother’s immune system may also play a role in the development of cholestasis. If this is the case, intravenous immunoglobulin may improve the infant’s survival.

Cholestasis can lead to a child not being able to eat normally. In such cases, high-calorie liquid feedings can be given via an NG tube. This tube is inserted through the nose, esophagus, or stomach. These liquids are meant to supplement the child’s diet or even replace meals if the child cannot eat.

liver disease Causes

Children with cholestasis have a variety of causes, including biliary atresia, blockages in bile ducts, and defects in the excretion of bile acids. The condition affects a growing proportion of children and adolescents and poses unique challenges for internists. This condition can significantly affect children’s quality of life and psychosocial functioning. There are also several differences between pediatric and adult forms of cholestasis. The disease is caused by genetic defects or mechanical obstruction of the biliary tract, such as biliary atresia.

Children with cholestasis should be evaluated as soon as possible. Although the underlying cause is unclear, the early postnatal stages of liver development are more prone to endogenous insults. Neonatal iron storage disease may also be a contributing factor to cholestasis. In addition, maternal alloimmunity may play a role in the pathogenesis of cholestasis. For this reason, administering intravenous immunoglobulin to mothers during pregnancy may improve infant survival.

Children with cholestasis may need additional blood tests to determine the extent of liver disease. These tests are non-invasive ways to diagnose and assess the severity of cholestasis.


Treatment of cholestasis symptoms involves surgery, medication, and diet. Cholestasis symptoms may be caused by a viral infection, bacterial infection, or parasite. These infections can interfere with bile flow, obstructing the bile ducts. Symptoms may also include failure to thrive. If left untreated, the condition can lead to cirrhosis. Medical treatment involves diet and medications, while surgical treatment involves external biliary diversions.

Children suffering from cholestasis often have itchy skin and mucous membranes. Cholestasis during pregnancy can also affect the baby, increasing the risk of stillbirth. Because of the risks to the fetus, pregnant women with this condition should seek medical attention if they experience these symptoms.

Treatment for cholestasis symptoms in children may involve removing the condition’s causes. For example, excess bile acid in the blood may cause liver damage, leading to premature birth and other complications. However, if detected and treated early, cholestasis in children can improve the chances of a full recovery.

Pregnancy hormones

Intrahepatic cholestasis during pregnancy (ICP) is one of the most common liver disorders of pregnancy, with increased risks of preterm labor and birth. This activity will discuss the pathophysiology, evaluation, and treatment of ICP and highlight the importance of interprofessional care coordination. This can improve pregnancy outcomes.

Early symptoms of pregnancy cholestasis may include a general feeling of being ill and severe itching of the hands or feet. The condition can also result in abnormal urine or stool color. Additionally, the affected woman may experience pale or yellow skin color, irritated skin, and little cuts in areas of scratching. Ultimately, cholestasis during pregnancy is usually not life-threatening, but it can be dangerous for the fetus and the mother.

Early detection and treatment of cholestasis during pregnancy are the key to preventing stillbirth. If a woman develops cholestasis during her pregnancy, she will be closely monitored by a healthcare provider. Usually, the symptoms will disappear within a few days after giving birth. However, if the symptoms persist after delivery, your provider may wish to check on your liver function to ensure that the pregnancy is proceeding as expected.